NVGT Humanized Mouse Model:
A New Era in Immune System Studies
Rescuing Lymph Node Development for Superior Immune Research
Traditional humanized mouse models like NSG and NOG lack functional lymph node development, compromising immune interactions. Our NVGT mice overcome this limitation by rescuing lymph node development, providing a physiologically relevant environment for studying immune responses.
Why Rescuing Lymph Node Development Matters:
🟢 Restored Lymph Node Development:
NVGT mice demonstrate functional lymphoid organogenesis with murine follicular dendritic cells (FDCs), enabling efficient immune interactions.
🧩 B-Cell Germinal Center Formation:
The presence of FDCs supports germinal center formation, crucial for antibody affinity maturation and long-term memory B-cell generation.
🛡️ Enhanced Antigen Presentation:
Increased development of dendritic cells (DCs) and monocyte-derived APCs supports cross-presentation of antigens, improving the study of vaccine responses and cancer immunotherapies.
🔍 Versatile Immune Research Platform:
NVGT mice can be customized to express specific HLA molecules or human cytokines, making them adaptable for diverse immunological studies.
🧪 NVGT Mouse Model Variants
Figure: Lymph Node Development in NVGT mice
Contact Us to discover how NVGT mice can accelerate your immunology research